Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.63 |
| ▸ | NCOR1 | O75376 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2733350 | 0.84 | HDAC1 (0.80) | HDAC1HDAC3HDAC2NCOR1MAPK1 | |
| SCHEMBL5265779 | 0.83 | HDAC1 (0.61) | HDAC1HDAC3HDAC2NCOR1MAPK1 | |
| SCHEMBL8401704 | 0.83 | HDAC1 (0.89) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| SCHEMBL211677 | 0.82 | HDAC1 (0.76) | HDAC1HDAC3HDAC2NCOR1MAPK1 | |
| SCHEMBL4715033 | 0.82 | HDAC1 (0.70) | HDAC1HDAC3HDAC2NCOR1MAPK1 | |
| SCHEMBL211107 | 0.82 | HDAC1 (0.70) | HDAC1HDAC3HDAC2NCOR1MAPK1 | |
| SCHEMBL8279067 | 0.81 | HDAC1 (0.71) | HDAC1HDAC3HDAC2NCOR1MAPK1 | |
| SCHEMBL14473033 | 0.81 | HDAC1 (0.68) | HDAC1HDAC3HDAC2NCOR1MAPK1 | |
| SCHEMBL8470457 | 0.81 | HDAC1 (0.68) | HDAC1HDAC3HDAC2NCOR1MAPK1 | |
| SCHEMBL2732292 | 0.81 | HDAC1 (0.70) | HDAC1HDAC3HDAC2NCOR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904452-A2 | HISTONE DEACETYLASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-04-02 | — | — | EP | claimed |
| WO-2007011626-A2 | HISTONE DEACETYLASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2007-01-25 | — | — | WO | claimed |
| EP-1904452-A2 | HISTONE DEACETYLASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007011626-A2 | HISTONE DEACETYLASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2007-01-25 | — | — | WO | disclosed |