Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 20/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 19/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 15/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.55 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL471512 | 0.87 | OPRD1 (0.73) | OPRD1KCNH2CYP2D6OPRM1OPRK1 | |
| SCHEMBL471533 | 0.84 | OPRD1 (0.78) | OPRD1KCNH2CYP2D6OPRM1OPRK1 | |
| SCHEMBL12262172 | 0.84 | OPRD1 (0.43) | OPRD1KCNH2CYP2D6OPRM1OPRK1 | |
| SCHEMBL16315260 | 0.83 | OPRD1 (0.43) | OPRD1KCNH2CYP2D6OPRM1OPRK1 | |
| SCHEMBL13676426 | 0.83 | OPRD1 (0.78) | OPRD1KCNH2CYP2D6OPRM1OPRK1 | |
| SCHEMBL12262225 | 0.83 | OPRD1 (0.45) | OPRD1KCNH2CYP2D6OPRM1OPRK1 | |
| SCHEMBL12030157 | 0.82 | OPRD1 (0.73) | OPRD1KCNH2CYP2D6OPRM1OPRK1 | |
| SCHEMBL471634 | 0.81 | OPRD1 (0.70) | OPRD1KCNH2CYP2D6OPRM1OPRK1 | |
| SCHEMBL10258409 | 0.80 | OPRD1 (0.81) | OPRD1KCNH2CYP2D6OPRM1OPRK1 | |
| Hydrochloric Acid SCHEMBL2070671 | 0.80 | OPRD1 (0.79) | OPRD1KCNH2CYP2D6OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2399577-A1 | Use of N-containing spirocompounds for the enhancement of cognitive function | Adolor Corporation (US) | 2011-12-28 | — | — | EP | disclosed |
| WO-2008033299-A2 | USE OF N-CONTAINING SPIROCOMPOUNDS FOR THE ENHANCEMENT OF COGNITIVE FUNCTION | ADOLOR CORPORATION (US) | 2008-03-20 | — | — | WO | disclosed |