Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MLNR | O43193 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4715155 | 0.79 | HRH3 (0.39) | HRH3KMT2ACYP2D6MEN1LMNA | |
| SCHEMBL24017137 | 0.78 | SIGMAR1 (0.55) | HRH3KMT2ACYP2D6MEN1LMNA | |
| SCHEMBL7294980 | 0.76 | HRH3 (0.42) | HRH3KMT2ACYP2D6MEN1LMNA | |
| SCHEMBL3029745 | 0.75 | CYP2D6 (0.44) | HRH3KMT2ACYP2D6MEN1LMNA | |
| SCHEMBL5258297 | 0.74 | HRH3 (0.38) | HRH3KMT2ACYP2D6MEN1LMNA | |
| SCHEMBL8860836 | 0.74 | SIGMAR1 (0.58) | SIGMAR1CYP1A2 | |
| SCHEMBL8861067 | 0.74 | SIGMAR1 (0.58) | SIGMAR1CYP1A2 | |
| SCHEMBL5663632 | 0.73 | HRH3 (0.45) | HRH3KMT2ACYP2D6MEN1LMNA | |
| SCHEMBL2090140 | 0.72 | HRH3 (0.44) | HRH3KMT2ACYP2D6MEN1LMNA | |
| SCHEMBL7303522 | 0.72 | S1PR1 (0.45) | HRH3KMT2ACYP2D6MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216230-B1 | FUSED CYCLOHEPTANE AND FUSED AZACYCLOHEPTANE COMPOUNDS AND THEIR USE AS INTEGRIN RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2008-04-23 | — | — | EP | disclosed |