Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 6/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.33 |
| ▸ | VEGFA | P15692 | 2/20 | 0.33 |
| ▸ | ARNT | P27540 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL508819 | 0.88 | KCNH2 (0.47) | KCNH2CYP3A4MAPTEPAS1VEGFA | |
| SCHEMBL509554 | 0.85 | KCNH2 (0.52) | KCNH2PGRPTGDR2RORC | |
| SCHEMBL14304003 | 0.84 | KCNH2 (0.49) | KCNH2PGRRORC | |
| SCHEMBL10251125 | 0.78 | KCNH2 (0.42) | KCNH2PGRPTGDR2 | |
| SCHEMBL14540679 | 0.77 | KCNH2 (0.47) | KCNH2CYP3A4MAPTEPAS1VEGFA | |
| SCHEMBL508737 | 0.76 | KCNH2 (0.42) | KCNH2PGRRORC | |
| SCHEMBL508806 | 0.76 | MAPT (0.41) | KCNH2MAPTPTGDR2 | |
| SCHEMBL508808 | 0.75 | CYP3A4 (0.38) | KCNH2CYP3A4EPAS1VEGFA | |
| SCHEMBL4720561 | 0.75 | KCNH2 (0.38) | KCNH2CYP3A4PGRRORC | |
| SCHEMBL508348 | 0.75 | ENPP3 (0.45) | KCNH2CYP3A4MAPTEPAS1VEGFA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551828-B1 | PYRAZOLE DERIVATIVES | PFIZER LTD (GB) | 2008-01-23 | — | — | EP | disclosed |