Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 16/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4716143 | 0.89 | TRPV1 (0.47) | TRPV1 | |
| SCHEMBL4718648 | 0.86 | TRPV1 (0.48) | TRPV1EPHX2KDM4EALDH1A1MAPT | |
| SCHEMBL4716131 | 0.85 | TRPV1 (0.62) | TRPV1EPHX2 | |
| SCHEMBL4717857 | 0.83 | TRPV1 (0.57) | TRPV1EPHX2KDM4EALDH1A1MAPT | |
| SCHEMBL4717837 | 0.83 | TRPV1 (0.64) | TRPV1EPHX2KDM4EALDH1A1MAPT | |
| SCHEMBL4716610 | 0.83 | TRPV1 (0.45) | TRPV1KDM4EALDH1A1MAPT | |
| SCHEMBL4716256 | 0.82 | ALDH1A1 (0.51) | TRPV1KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4719471 | 0.82 | TRPV1 (0.55) | TRPV1EPHX2KDM4EALDH1A1MAPT | |
| SCHEMBL4719798 | 0.81 | TRPV1 (0.54) | TRPV1EPHX2ROCK2 | |
| SCHEMBL4825028 | 0.81 | ALDH1A1 (0.47) | TRPV1EPHX2KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442701-B2 | Amino-heterocycles as VR-1 antagonists for treating pain | MERCK SHARP & DOHME LTD. (GB) | 2008-10-28 | — | — | US | disclosed |
| EP-1562934-B1 | AMINO-HETEROCYCLES AS VR-1 ANTAGONISTS FOR TREATING PAIN | MERCK SHARP & DOHME (GB) | 2008-03-26 | — | — | EP | disclosed |
| US-20060040947-A1 | Amino-heterocycles as vr-1 antagonists for treating pain | MERCK SHARP & DOHME LTD. (GB) | 2006-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060040947-A1 | Amino-heterocycles as vr-1 antagonists for treating pain | OPRL1, CNR1, GPR6 | TRPV1 40/4885EPHX2 2062/4885KDM4E 4502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.