Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | MMP10 | P09238 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HBB | P68871 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5616146 | 0.90 | MMP13 (0.63) | MMP13POLBMMP10MMP9MMP8 | |
| SCHEMBL4719854 | 0.85 | MMP13 (0.68) | MMP13MMP10MMP9MMP8KMT2A | |
| SCHEMBL4715755 | 0.82 | MMP13 (0.67) | MMP13POLBMMP10MMP9MMP8 | |
| SCHEMBL4716774 | 0.81 | MMP13 (0.68) | MMP13MMP10MMP9MMP8LMNA | |
| SCHEMBL4717829 | 0.81 | CD274 (0.57) | MMP13ALDH1A1 | |
| SCHEMBL4718606 | 0.80 | MMP13 (0.63) | MMP13MMP10MMP9MMP8HSD17B10 | |
| SCHEMBL29838134 | 0.79 | MMP13 (1.00) | MMP13POLBMMP10MMP9MMP8 | |
| SCHEMBL8358823 | 0.79 | MMP13 (1.00) | MMP13POLBMMP10MMP9MMP8 | |
| SCHEMBL8335071 | 0.78 | MMP13 (0.69) | MMP13MMP10MMP9MMP8KMT2A | |
| SCHEMBL4716624 | 0.78 | MMP13 (0.66) | MMP13POLBMMP10MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560815-B1 | NOVEL PYRIMIDINE-4,6-DICARBOXAMIDES FOR THE SELECTIVE INHIBITION OF COLLAGENASES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2008-03-12 | — | — | EP | claimed |
| US-7166609-B2 | Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-01-23 | — | — | US | disclosed |
| US-7166609-B2 | Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-01-23 | — | — | US | disclosed |