Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19150630 | 0.86 | GRIN2D (0.55) | LMNAMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL4718085 | 0.79 | MEN1 (0.76) | LMNAMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL4718166 | 0.78 | LMNA (0.66) | LMNAMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL2734797 | 0.76 | MEN1 (0.52) | LMNAMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL132328 | 0.76 | SPHK2 (0.59) | LMNAMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL133608 | 0.74 | SPHK2 (0.58) | LMNAMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL2948683 | 0.74 | POLB (0.54) | LMNAMEN1KMT2AHTTSPHK2 | |
| SCHEMBL1548365 | 0.73 | SPHK2 (0.57) | LMNAMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL1548965 | 0.72 | MEN1 (0.61) | LMNAMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL1548582 | 0.72 | MEN1 (0.57) | LMNAMEN1KMT2AHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017060771-A2 | COMBINATION THERAPIES FOR TREATING CANCER | REDHILL BIOPHARMA LTD. (IL) | 2017-04-13 | — | — | WO | disclosed |
| EP-1904439-A2 | SPHINGOSINE KINASE INHIBITORS | Apogee Biothechnology Corporation (US) | 2008-04-02 | — | — | EP | disclosed |
| WO-2006138660-A2 | SPHINGOSINE KINASE INHIBITORS | APOGEE BIOTECHNOLOGY CORPORATION (US) | 2006-12-28 | — | — | WO | disclosed |