Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 20/20 | 0.84 |
| ▸ | CTSS | P25774 | 15/20 | 0.84 |
| ▸ | CTSL | P07711 | 13/20 | 0.84 |
| ▸ | CTSB | P07858 | 13/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4712362 | 0.91 | CTSK (1.00) | CTSKCTSSCTSLCTSB | |
| SCHEMBL4713519 | 0.91 | CTSK (1.00) | CTSKCTSSCTSLCTSB | |
| SCHEMBL4714184 | 0.90 | CTSK (0.81) | CTSKCTSSCTSLCTSB | |
| SCHEMBL4712035 | 0.90 | CTSK (1.00) | CTSKCTSSCTSLCTSB | |
| SCHEMBL4716044 | 0.89 | CTSK (1.00) | CTSKCTSSCTSLCTSB | |
| SCHEMBL1587727 | 0.89 | CTSK (1.00) | CTSKCTSSCTSLCTSB | |
| SCHEMBL4714581 | 0.89 | CTSK (1.00) | CTSKCTSSCTSLCTSB | |
| SCHEMBL4713554 | 0.88 | CTSK (1.00) | CTSKCTSSCTSLCTSB | |
| SCHEMBL4714700 | 0.87 | CTSK (1.00) | CTSKCTSSCTSLCTSB | |
| SCHEMBL14290844 | 0.86 | CTSK (0.77) | CTSKCTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1248612-B1 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2008-02-27 | — | — | EP | claimed |
| EP-1248612-A4 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | MERCK FROSST CANADA INC (CA) | 2005-09-07 | — | — | EP | claimed |
| EP-1248612-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | MERCK FROSST CANADA INC. (CA) | 2002-10-16 | — | — | EP | claimed |
| WO-2001049288-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2001-07-12 | — | — | WO | claimed |