Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 10/20 | 0.54 |
| ▸ | TP53 | P04637 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.46 |
| ▸ | HTR3A | P46098 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30298447 | 0.79 | EPHX2 (0.54) | EPHX2TP53SMN1; SMN2KCNA5CHRNA7 | |
| SCHEMBL11450556 | 0.79 | EPHX2 (0.54) | EPHX2TP53SMN1; SMN2KCNA5CHRNA7 | |
| SCHEMBL14804986 | 0.76 | EPHX2 (0.81) | EPHX2TP53SMN1; SMN2KCNA5CHRNA7 | |
| SCHEMBL12380221 | 0.75 | EPHX2 (0.50) | EPHX2TP53SMN1; SMN2KCNA5CHRNA7 | |
| SCHEMBL7454410 | 0.75 | EPHX2 (0.50) | EPHX2TP53SMN1; SMN2KCNA5CHRNA7 | |
| SCHEMBL18232975 | 0.75 | KCNA5 (0.56) | EPHX2TP53SMN1; SMN2KCNA5CHRNA7 | |
| SCHEMBL7089986 | 0.73 | SMN1; SMN2 (0.63) | EPHX2TP53SMN1; SMN2KCNA5MAPT | |
| SCHEMBL6866395 | 0.72 | KCNA5 (0.50) | EPHX2TP53SMN1; SMN2KCNA5CHRNA7 | |
| SCHEMBL2125837 | 0.72 | SMN1; SMN2 (0.57) | EPHX2TP53SMN1; SMN2MAPT | |
| SCHEMBL4741893 | 0.72 | EPHX2 (0.71) | EPHX2SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937669-A1 | NOVEL BENZOPYRAN DERIVATIVES AS POTASSIUM CHANNEL OPENERS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007027959-A1 | NOVEL BENZOPYRAN DERIVATIVES AS POTASSIUM CHANNEL OPENERS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-03-08 | — | — | WO | disclosed |