Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.63 |
| ▸ | TP53 | P04637 | 6/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.53 |
| ▸ | FAAH | O00519 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.49 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.49 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexane SCHEMBL2446980 | 0.95 | TP53 (0.58) | SMN1; SMN2TP53MAPTHIF1AEPHX2 | |
| SCHEMBL8282242 | 0.85 | TP53 (0.78) | SMN1; SMN2TP53MAPTHIF1AEPHX2 | |
| SCHEMBL896377 | 0.81 | TP53 (0.56) | SMN1; SMN2TP53MAPTHIF1AEPHX2 | |
| SCHEMBL2438375 | 0.80 | SMN1; SMN2 (0.57) | SMN1; SMN2TP53MAPTHIF1AEPHX2 | |
| SCHEMBL2125837 | 0.80 | SMN1; SMN2 (0.57) | SMN1; SMN2TP53MAPTHIF1AEPHX2 | |
| SCHEMBL14427258 | 0.80 | SMN1; SMN2 (0.57) | SMN1; SMN2TP53MAPTHIF1AEPHX2 | |
| SCHEMBL30921555 | 0.80 | SMN1; SMN2 (0.75) | SMN1; SMN2TP53MAPTHIF1AALOX15 | |
| SCHEMBL17404483 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2TP53MAPTHIF1AEPHX2 | |
| SCHEMBL2785316 | 0.79 | TP53 (0.52) | SMN1; SMN2TP53MAPTHIF1AEPHX2 | |
| SCHEMBL9828963 | 0.78 | KCNA5 (0.55) | SMN1; SMN2TP53MAPTHIF1AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294716-A1 | LACTAM INHIBITORS OF FACTOR XA AND METHOD | Bristol-Myers Squibb Company (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001096331-A1 | LACTAM INHIBITORS OF FACTOR XA AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |