Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | RPS6KA5 | O75582 | 13/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.55 |
| ▸ | AKT1 | P31749 | 5/20 | 0.55 |
| ▸ | AKT2 | P31751 | 5/20 | 0.55 |
| ▸ | AKT3 | Q9Y243 | 5/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.55 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4719598 | 0.82 | RPS6KA5 (0.63) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL4000617 | 0.81 | RPS6KA5 (0.58) | TSHRMEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL5457890 | 0.79 | RPS6KA5 (0.56) | TSHRMEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL4716087 | 0.78 | RPS6KA5 (0.55) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL4716175 | 0.77 | RPS6KA5 (0.61) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL4761478 | 0.74 | RPS6KA5 (0.73) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL4718346 | 0.74 | RPS6KA5 (0.62) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL14252546 | 0.74 | RPS6KA5 (0.71) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL4761981 | 0.74 | RPS6KA5 (0.59) | RPS6KA5ROCK1AKT1AKT2AKT3 | |
| SCHEMBL4718746 | 0.74 | RPS6KA5 (0.65) | RPS6KA5ROCK1AKT1AKT2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490367-B1 | IMIDAZOPYRIDINE DERIVATIVES AS KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-07-23 | — | — | EP | disclosed |