Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.47 |
| ▸ | AURKA | O14965 | 5/20 | 0.47 |
| ▸ | GSK3A | P49840 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
| ▸ | BCL6 | P41182 | 1/20 | 0.44 |
| ▸ | ITK | Q08881 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | RHOA | P61586 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.42 |
| ▸ | IGF1R | P08069 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4716354 | 1.00 | GSK3B (0.47) | GSK3BAURKAGSK3AHDAC6JAK2 | |
| SCHEMBL4714877 | 0.83 | EGFR (0.50) | AURKAITKEGFRRAB9ANPC1 | |
| SCHEMBL4714874 | 0.83 | EGFR (0.50) | AURKAITKEGFRRAB9ANPC1 | |
| SCHEMBL4714696 | 0.81 | BCL6 (0.50) | GSK3BAURKAGSK3AHDAC6JAK2 | |
| SCHEMBL4715101 | 0.78 | EGFR (0.47) | GSK3BAURKAGSK3AJAK2AURKB | |
| SCHEMBL4715103 | 0.78 | EGFR (0.47) | GSK3BAURKAGSK3AJAK2AURKB | |
| SCHEMBL20953571 | 0.74 | RAB9A (0.59) | GSK3BAURKAGSK3AJAK2AURKB | |
| SCHEMBL25345948 | 0.73 | PLAU (0.44) | HDAC6RAB9ATSHRNFKB1CLK4 | |
| SCHEMBL10187855 | 0.71 | BCL6 (0.53) | GSK3BAURKAGSK3AJAK2AURKB | |
| SCHEMBL28223543 | 0.71 | JAK2 (0.62) | GSK3BAURKAGSK3AJAK2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0964864-B1 | PYRIDO 2,3-D PYRIMIDINES AND 4-AMINOPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2008-04-09 | — | — | EP | claimed |