Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 14/20 | 0.76 |
| ▸ | MMP10 | P09238 | 5/20 | 0.63 |
| ▸ | MMP8 | P22894 | 5/20 | 0.63 |
| ▸ | MMP9 | P14780 | 1/20 | 0.63 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.38 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718343 | 0.90 | MMP13 (0.74) | MMP13MMP10MMP8MMP9HCRTR1 | |
| SCHEMBL8358823 | 0.87 | MMP13 (1.00) | MMP13MMP10MMP8MMP9HCRTR1 | |
| SCHEMBL29838134 | 0.87 | MMP13 (1.00) | MMP13MMP10MMP8MMP9HCRTR1 | |
| SCHEMBL4716566 | 0.85 | MMP13 (0.90) | MMP13MMP10MMP8MMP9HCRTR1 | |
| SCHEMBL14308577 | 0.84 | MMP13 (0.83) | MMP13MMP10MMP8MMP9HCRTR1 | |
| SCHEMBL8360162 | 0.84 | MMP13 (0.88) | MMP13MMP10MMP8MMP9HCRTR1 | |
| SCHEMBL12272887 | 0.83 | MMP13 (0.92) | MMP13MMP10MMP8MMP9HCRTR1 | |
| SCHEMBL5616128 | 0.83 | MMP13 (0.86) | MMP13MMP10MMP8MMP9HCRTR1 | |
| SCHEMBL8357428 | 0.82 | MMP13 (0.90) | MMP13MMP10MMP8MMP9 | |
| SCHEMBL14284143 | 0.82 | MMP13 (0.90) | MMP13MMP10MMP8MMP9HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560815-B1 | NOVEL PYRIMIDINE-4,6-DICARBOXAMIDES FOR THE SELECTIVE INHIBITION OF COLLAGENASES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2008-03-12 | — | — | EP | disclosed |
| EP-1587803-A1 | PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES FOR USE AS SELECTIVE MMP 13 INHIBITORS | Aventis Pharma Deutschland GmbH (DE) | 2005-10-26 | — | — | EP | disclosed |
| EP-1560815-A1 | NOVEL PYRIMIDINE-4,6-DICARBOXAMIDES FOR THE SELECTIVE INHIBITION OF COLLAGENASES | Aventis Pharma Deutschland GmbH (DE) | 2005-08-10 | — | — | EP | disclosed |
| WO-2004060883-A1 | PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES FOR USE AS SELECTIVE MMP 13 INHIBITORS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-07-22 | — | — | WO | disclosed |
| WO-2004041788-A1 | NOVEL PYRIMIDINE-4,6-DICARBOXAMIDES FOR THE SELECTIVE INHIBITION OF COLLAGENASES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-05-21 | — | — | WO | disclosed |