Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 5/20 | 0.46 |
| ▸ | TEK | Q02763 | 4/20 | 0.46 |
| ▸ | KDR | P35968 | 9/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | DDX3X | O00571 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | BCR | P11274 | 2/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4791492 | 0.85 | KDR (0.43) | LCKTEKKDRPDGFRBDDX3X | |
| SCHEMBL4717717 | 0.84 | ACACB (0.37) | KDRPDGFRBKITPDGFRA | |
| SCHEMBL4720860 | 0.78 | KDR (0.57) | LCKTEKKDRPDGFRBDDX3X | |
| SCHEMBL4719789 | 0.77 | LCK (0.54) | LCKTEKKDRPDGFRBGRM5 | |
| SCHEMBL4714699 | 0.77 | MEN1 (0.57) | LCKTEKKDR | |
| SCHEMBL4720016 | 0.76 | RAF1 (0.52) | LCKTEKKDRPDGFRB | |
| SCHEMBL4715827 | 0.76 | MEN1 (0.60) | LCKTEKKDRGRM5 | |
| SCHEMBL4717511 | 0.74 | LCK (0.56) | LCKTEKKDRGRM5 | |
| SCHEMBL4717465 | 0.74 | LCK (0.56) | LCKTEKKDRPDGFRBDDX3X | |
| SCHEMBL4714883 | 0.74 | CDK8 (0.56) | LCKTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737463-B1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2008-12-03 | — | — | EP | disclosed |