Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.43 |
| ▸ | LCK | P06239 | 3/20 | 0.43 |
| ▸ | TEK | Q02763 | 3/20 | 0.43 |
| ▸ | KCNJ6 | P48051 | 4/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 4/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 4/20 | 0.39 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 5/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | DDX3X | O00571 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4716830 | 0.85 | LCK (0.46) | KDRLCKTEKPDGFRBDDX3X | |
| SCHEMBL4791064 | 0.81 | CCR3 (0.42) | CCR3 | |
| SCHEMBL4791129 | 0.80 | CCR3 (0.42) | LCKCCR3 | |
| SCHEMBL4720860 | 0.76 | KDR (0.57) | KDRLCKTEKPDGFRBPOLB | |
| SCHEMBL4714699 | 0.75 | MEN1 (0.57) | KDRLCKTEKPOLB | |
| SCHEMBL4715827 | 0.74 | MEN1 (0.60) | KDRLCKTEKKCNJ6KCNJ5 | |
| SCHEMBL4714635 | 0.74 | MAP4K4 (0.53) | KDRLCKTEKPOLB | |
| SCHEMBL4717465 | 0.73 | LCK (0.56) | KDRLCKTEKPDGFRBPOLB | |
| SCHEMBL4719789 | 0.73 | LCK (0.54) | KDRLCKTEKPDGFRBPOLB | |
| SCHEMBL4717511 | 0.73 | LCK (0.56) | KDRLCKTEKPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737463-B1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2008-12-03 | — | — | EP | claimed |