Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.36 |
| ▸ | FEN1 | P39748 | 4/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | FABP6 | P51161 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18053842 | 0.89 | JAK2 (0.37) | MAPTALDH1A1GAAHSD17B10GRM5 | |
| SCHEMBL23860863 | 0.81 | ALDH1A1 (0.40) | MAPTALDH1A1GAAHSD17B10GRM5 | |
| SCHEMBL29364018 | 0.81 | ALDH1A1 (0.40) | MAPTALDH1A1GAAHSD17B10GRM5 | |
| SCHEMBL13212813 | 0.78 | ALDH1A1 (0.40) | MAPTALDH1A1GAAHSD17B10GRM5 | |
| SCHEMBL2596436 | 0.78 | MAPT (0.40) | MAPTALDH1A1GAAHSD17B10GRM5 | |
| SCHEMBL29659230 | 0.78 | MAPT (0.40) | MAPTALDH1A1GAAHSD17B10GRM5 | |
| SCHEMBL6107503 | 0.78 | ALDH1A1 (0.40) | MAPTALDH1A1GAAHSD17B10GRM5 | |
| SCHEMBL4716839 | 0.78 | ALDH1A1 (0.40) | MAPTALDH1A1GAAHSD17B10GRM5 | |
| SCHEMBL2492111 | 0.78 | GAA (0.47) | MAPTALDH1A1GAAHSD17B10GRM5 | |
| SCHEMBL21400681 | 0.74 | ALDH1A1 (0.44) | MAPTALDH1A1GAAHSD17B10GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008093065-A1 | L-ALANINE DERIVATIVES AS α5βL ANTAGONISTS | ASTRAZENECA AB (SE) | 2008-08-07 | — | — | WO | disclosed |
| EP-1216230-B1 | FUSED CYCLOHEPTANE AND FUSED AZACYCLOHEPTANE COMPOUNDS AND THEIR USE AS INTEGRIN RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2008-04-23 | — | — | EP | disclosed |