Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 5/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CCR8 | P51685 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | PKLR | P30613 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4716229 | 0.88 | CCR8 (0.42) | PKMCYP19A1CCR8SMN1; SMN2LMNA | |
| SCHEMBL4717181 | 0.83 | CCR8 (0.41) | CCR8 | |
| SCHEMBL4720275 | 0.83 | CCR8 (0.41) | CCR8 | |
| SCHEMBL3922158 | 0.78 | CCR8 (0.49) | CCR8KCNH2 | |
| SCHEMBL3930790 | 0.78 | CCR8 (0.49) | CCR8KCNH2 | |
| SCHEMBL3918417 | 0.78 | CCR8 (0.49) | CCR8KCNH2 | |
| SCHEMBL3920296 | 0.74 | KCNH2 (0.50) | CCR8KCNH2 | |
| SCHEMBL4720202 | 0.74 | CCR8 (0.54) | CCR8LMNAKCNH2 | |
| SCHEMBL3930784 | 0.73 | CCR8 (0.49) | CCR8KCNH2 | |
| SCHEMBL3922150 | 0.73 | CCR8 (0.49) | CCR8KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567520-B1 | QUINOLINES AND NITROGENATED DERIVATIVES THEREOF AND THEIR USE AS ANTIBACTERIAL AGENTS | GLAXO GROUP LTD (GB) | 2008-10-15 | — | — | EP | claimed |