Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 6/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | GPR17 | Q13304 | 6/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29010008 | 0.88 | FFAR4 (0.51) | FFAR1FFAR4 | |
| SCHEMBL28805647 | 0.85 | CES2 (0.40) | FFAR1FFAR4GPR17CES2CES1 | |
| SCHEMBL19522398 | 0.85 | GPR17 (0.55) | FFAR1FFAR4KEAP1GPR17 | |
| SCHEMBL4718220 | 0.82 | CES2 (0.38) | FFAR1FFAR4GPR17CES2CES1 | |
| SCHEMBL27037031 | 0.81 | FFAR1 (0.50) | FFAR1FFAR4KEAP1GPR17CES2 | |
| SCHEMBL4714927 | 0.81 | FFAR1 (0.59) | FFAR1FFAR4KEAP1GPR17CES2 | |
| SCHEMBL29459948 | 0.78 | AKR1B1 (0.43) | FFAR4CES2CES1ALDH1A1 | |
| SCHEMBL909585 | 0.78 | AKR1B1 (0.43) | FFAR4CES2CES1ALDH1A1 | |
| SCHEMBL4717045 | 0.78 | FFAR1 (0.49) | FFAR1FFAR4KEAP1CES2CES1 | |
| SCHEMBL20889396 | 0.77 | NPSR1 (0.44) | FFAR1FFAR4KEAP1GPR17MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1337517-B1 | PYRIMIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 2008-11-26 | — | — | EP | disclosed |