Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 15/20 | 0.64 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4717594 | 0.99 | RPS6KA5 (0.63) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| SCHEMBL14252436 | 0.95 | RPS6KA5 (0.64) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| Hydrochloric Acid SCHEMBL4715944 | 0.94 | RPS6KA5 (0.63) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| SCHEMBL4715629 | 0.90 | RPS6KA5 (0.64) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| SCHEMBL4718781 | 0.88 | RPS6KA5 (0.62) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| SCHEMBL4720804 | 0.88 | RPS6KA5 (0.67) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| SCHEMBL4714498 | 0.88 | RPS6KA5 (0.72) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| SCHEMBL6648964 | 0.87 | RPS6KA5 (0.72) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| Hydrochloric Acid SCHEMBL4717613 | 0.87 | RPS6KA5 (0.61) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| SCHEMBL4762237 | 0.87 | RPS6KA5 (0.58) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490367-B1 | IMIDAZOPYRIDINE DERIVATIVES AS KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-07-23 | — | — | EP | disclosed |