Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 14/20 | 0.58 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14252436 | 0.89 | RPS6KA5 (0.64) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| SCHEMBL5468933 | 0.89 | RPS6KA5 (0.59) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| Hydrochloric Acid SCHEMBL4715944 | 0.89 | RPS6KA5 (0.63) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| SCHEMBL4717439 | 0.87 | RPS6KA5 (0.64) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| SCHEMBL4763679 | 0.87 | RPS6KA5 (0.57) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| SCHEMBL4762640 | 0.86 | RPS6KA5 (0.58) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| Hydrochloric Acid SCHEMBL4717594 | 0.86 | RPS6KA5 (0.63) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| SCHEMBL4718781 | 0.86 | RPS6KA5 (0.62) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| SCHEMBL4717291 | 0.86 | RPS6KA5 (0.62) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 | |
| SCHEMBL5467956 | 0.86 | RPS6KA5 (0.57) | RPS6KA5RPS6KB1ROCK1DYRK1ACDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689393-A4 | PREPARATION OF 1,7-DISUBSTITUTED AZABENZIMIDAZOLES AS KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-12-17 | — | — | EP | claimed |
| US-20070123561-A1 | Preparation of 1,7-disubstituted azabensimidazoles as kinase inhibitors | LEE DENNIS | 2007-05-31 | — | — | US | claimed |
| JP-2007507547-A | — | — | 2007-03-29 | — | — | JP | claimed |
| EP-1689393-A2 | PREPARATION OF 1,7-DISUBSTITUTED AZABENZIMIDAZOLES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-08-16 | — | — | EP | claimed |
| WO-2005037198-A2 | PREPARATION OF 1,7-DISUBSTITUTED AZABENZIMIDAZOLES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-04-28 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123561-A1 | Preparation of 1,7-disubstituted azabensimidazoles as kinase inhibitors | TNK2, CDC42BPB, CDC42BPA | RPS6KA5 117/4885RPS6KB1 93/4885ROCK1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.