⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4286663 | 0.71 | HPGDS (0.30) | — | |
| SCHEMBL1047665 | 0.67 | — | — | |
| SCHEMBL1047666 | 0.67 | — | — | |
| SCHEMBL11455275 | 0.67 | — | — | |
| SCHEMBL9608311 | 0.67 | — | — | |
| SCHEMBL2944099 | 0.67 | — | — | |
| SCHEMBL1259564 | 0.64 | — | — | |
| SCHEMBL9601119 | 0.62 | — | — | |
| SCHEMBL1680430 | 0.62 | — | — | |
| SCHEMBL21631871 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404317-B1 | 5-HALO-TRYPTAMINE DERIVATIVES USED AS LIGANDS OF THE 5-HT 6? AND/OR 5-HT 7? SEROTONIN RECEPTORS | SIGMA TAU IND FARMACEUTI (IT) | 2008-12-10 | — | — | EP | disclosed |
| US-7098233-B2 | 5-halo-tryptamine derivatives used as ligands on the 5-HT6 and/or 5-HT7 serotonin receptors | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2006-08-29 | — | — | US | disclosed |
| US-6875771-B2 | Pyridopyrimidine derivatives as 5-HT6 antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-04-05 | — | — | US | disclosed |
| US-20040235899-A1 | 5-halo-tryptamine derivatives used as ligands of the 5-ht6 and/or 5-ht7 serotonin receptors | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2004-11-25 | — | — | US | disclosed |
| US-6737426-B1 | SUCH AS (4-PHENYLSULFONYL-2-PYRIDIN-3-YL-OXAZOL-5-YL)-METHYLAMINE; ANTICONVULSANTS, ANTIINFLAMMATORIES, NEURO-PROTECTANTS, CEREBROPROTECTANTS, NOOTROPICS | MERCK PATENT GMBH (DE) | 2004-05-18 | — | — | US | disclosed |
| US-6737426-B1 | SUCH AS (4-PHENYLSULFONYL-2-PYRIDIN-3-YL-OXAZOL-5-YL)-METHYLAMINE; ANTICONVULSANTS, ANTIINFLAMMATORIES, NEURO-PROTECTANTS, CEREBROPROTECTANTS, NOOTROPICS | MERCK PATENT GMBH (DE) | 2004-05-18 | — | — | US | disclosed |
| CN-1146549-C | Sulphoneylxazolamines as therapeutic active ingredients | Ĭ��ר���ɷ�����˾ | 2004-04-21 | — | — | CN | disclosed |
| US-20040019064-A1 | Pyridopyrimidine derivatives as 5-HT6 antagonists | WU YONG-JIN (US) | 2004-01-29 | — | — | US | disclosed |
| WO-2002100842-A1 | SULFONYLOXAZOLAMINES AND THEIR USE AS 5-HT6 LIGANDS | MERCK PATENT GMBH (DE) | 2002-12-19 | — | — | WO | disclosed |
| WO-2002100842-A1 | SULFONYLOXAZOLAMINES AND THEIR USE AS 5-HT6 LIGANDS | MERCK PATENT GMBH (DE) | 2002-12-19 | — | — | WO | disclosed |
| EP-1233963-A2 | NOVEL SULFONYL OXAZOLE AMINES | MERCK PATENT GmbH (DE) | 2002-08-28 | — | — | EP | disclosed |
| US-6441013-B1 | 5-HT6 RECEPTOR ANTAGONISTS FOR TREATING CENTRAL NERVOUS SYSTEM DISORDERS | MERCK PATENT GMBH (DE) | 2002-08-27 | — | — | US | disclosed |
| US-6441013-B1 | 5-HT6 RECEPTOR ANTAGONISTS FOR TREATING CENTRAL NERVOUS SYSTEM DISORDERS | MERCK PATENT GMBH (DE) | 2002-08-27 | — | — | US | disclosed |
| US-6441013-B1 | 5-HT6 RECEPTOR ANTAGONISTS FOR TREATING CENTRAL NERVOUS SYSTEM DISORDERS | MERCK PATENT GMBH (DE) | 2002-08-27 | — | — | US | disclosed |
| CN-1331684-A | Sulphoneylxazolamines as therapeutic active ingredients | MERCK PATENT GMBH (DE) | 2002-01-16 | — | — | CN | disclosed |
| EP-1140875-A1 | SULPHONYLOXAZOLAMINES AS THERAPEUTIC ACTIVE INGREDIENTS | MERCK PATENT GmbH (DE) | 2001-10-10 | — | — | EP | disclosed |
| EP-1140875-A1 | SULPHONYLOXAZOLAMINES AS THERAPEUTIC ACTIVE INGREDIENTS | MERCK PATENT GmbH (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2001038316-A2 | SULFONYL OXAZOLE AMINES AND THEIR USE AS 5-HT6 RECEPTOR LIGANDS | MERCK PATENT GMBH (DE) | 2001-05-31 | — | — | WO | disclosed |
| WO-2000037452-A1 | SULPHONYLOXAZOLAMINES AS THERAPEUTIC ACTIVE INGREDIENTS | MERCK PATENT GMBH (DE) | 2000-06-29 | — | — | WO | disclosed |
| WO-2000037452-A1 | SULPHONYLOXAZOLAMINES AS THERAPEUTIC ACTIVE INGREDIENTS | MERCK PATENT GMBH (DE) | 2000-06-29 | — | — | WO | disclosed |