Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 13/20 | 0.64 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.57 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.57 |
| ▸ | CDK2 | P24941 | 1/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.57 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.57 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718418 | 0.97 | RPS6KA5 (0.63) | RPS6KA5DYRK1ARPS6KB1CDK2ROCK1 | |
| SCHEMBL6647038 | 0.85 | RPS6KA5 (0.72) | RPS6KA5DYRK1ARPS6KB1CDK2ROCK1 | |
| SCHEMBL4718484 | 0.80 | RPS6KA5 (0.55) | RPS6KA5DYRK1ARPS6KB1CDK2ROCK1 | |
| SCHEMBL7499604 | 0.80 | STING1 (0.49) | DYRK1ASTING1 | |
| SCHEMBL4715639 | 0.79 | RPS6KA5 (0.64) | RPS6KA5DYRK1ARPS6KB1CDK2ROCK1 | |
| SCHEMBL4719459 | 0.79 | RPS6KA5 (1.00) | RPS6KA5DYRK1ARPS6KB1CDK2ROCK1 | |
| Trifluoroacetic Acid SCHEMBL4717303 | 0.77 | RPS6KA5 (0.52) | RPS6KA5DYRK1ARPS6KB1CDK2ROCK1 | |
| SCHEMBL4717136 | 0.74 | RPS6KA5 (1.00) | RPS6KA5DYRK1ARPS6KB1CDK2ROCK1 | |
| SCHEMBL4809663 | 0.71 | DYRK1A (0.74) | RPS6KA5DYRK1ARPS6KB1CDK2ROCK1 | |
| SCHEMBL14252445 | 0.71 | RPS6KA5 (0.64) | RPS6KA5DYRK1ARPS6KB1CDK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490367-B1 | IMIDAZOPYRIDINE DERIVATIVES AS KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-07-23 | — | — | EP | disclosed |