Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 3/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | LATS1 | O95835 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 9/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718418 | 0.83 | RPS6KA5 (0.63) | STING1DYRK1A | |
| SCHEMBL15176651 | 0.81 | BRD4 (0.62) | STING1BRD4CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8322503 | 0.81 | KDM4E (0.41) | — | |
| SCHEMBL10388938 | 0.81 | RPS6KA5 (0.45) | DYRK1A | |
| SCHEMBL4717657 | 0.80 | RPS6KA5 (0.64) | STING1DYRK1A | |
| SCHEMBL5344983 | 0.75 | DYRK1A (0.47) | STING1DYRK1ABRD4 | |
| SCHEMBL8883493 | 0.75 | PTAFR (0.51) | — | |
| SCHEMBL8882903 | 0.74 | PTAFR (0.49) | — | |
| SCHEMBL10388556 | 0.74 | PTAFR (0.48) | — | |
| SCHEMBL8321832 | 0.74 | GAA (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0734386-B1 | PLATELET ACTIVATING FACTOR ANTAGONISTS: IMIDAZOPYRIDINE INDOLES | ABBOTT LAB (US) | 2002-02-06 | — | — | EP | disclosed |
| EP-0734386-A1 | PLATELET ACTIVATING FACTOR ANTAGONISTS: IMIDAZOPYRIDINE INDOLES | Abbott Laboratories (US) | 1996-10-02 | — | — | EP | disclosed |
| US-5486525-A | ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES (US) | 1996-01-23 | — | — | US | disclosed |
| WO-1995016687-A1 | PLATELET ACTIVATING FACTOR ANTAGONISTS: IMIDAZOPYRIDINE INDOLES | ABBOTT LABORATORIES (US) | 1995-06-22 | — | — | WO | disclosed |