Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 19/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13294111 | 0.83 | HSD11B1 (0.58) | HSD11B1 | |
| SCHEMBL1407231 | 0.81 | POLB (0.49) | HSD11B1POLBMAPTSMN1; SMN2 | |
| SCHEMBL13294041 | 0.81 | HSD11B1 (0.58) | HSD11B1 | |
| SCHEMBL13294048 | 0.80 | HSD11B1 (0.57) | HSD11B1 | |
| SCHEMBL1406647 | 0.79 | POLB (0.49) | HSD11B1POLBMAPTSMN1; SMN2 | |
| SCHEMBL4718475 | 0.78 | HSD11B1 (0.40) | HSD11B1POLBMAPTSMN1; SMN2 | |
| SCHEMBL13294070 | 0.78 | HSD11B1 (0.60) | HSD11B1 | |
| SCHEMBL1406716 | 0.78 | HSD11B1 (0.60) | HSD11B1 | |
| SCHEMBL27172741 | 0.78 | POLB (0.48) | HSD11B1POLBMAPTSMN1; SMN2 | |
| SCHEMBL1406795 | 0.78 | POLB (0.48) | HSD11B1POLBMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1999114-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. Hoffmann-la Roche AG (CH) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007107470-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-27 | — | — | WO | disclosed |