Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.44 |
| ▸ | HPGD | P15428 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | TRPC1 | P48995 | 2/20 | 0.44 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.44 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.44 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.44 |
| ▸ | STIM2 | Q9P246 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4719065 | 0.99 | LMNA (0.45) | LMNAKDM4EHPGDALDH1A1MAPT | |
| SCHEMBL1407011 | 0.95 | LMNA (0.50) | LMNAKDM4EHPGDALDH1A1MAPT | |
| SCHEMBL1407035 | 0.94 | LMNA (0.48) | LMNAKDM4EHPGDALDH1A1MAPT | |
| SCHEMBL1407189 | 0.92 | TRPC1 (0.47) | LMNAKDM4EHPGDALDH1A1MAPT | |
| SCHEMBL1406984 | 0.90 | TRPC1 (0.49) | LMNAKDM4EHPGDALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL4717917 | 0.87 | LMNA (0.46) | LMNAKDM4EHPGDALDH1A1MAPT | |
| SCHEMBL1406795 | 0.87 | POLB (0.48) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL27172741 | 0.87 | POLB (0.48) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4720818 | 0.86 | LMNA (0.44) | LMNAKDM4EHPGDALDH1A1MAPT | |
| SCHEMBL1406647 | 0.86 | POLB (0.49) | KDM4EALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1999114-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. Hoffmann-la Roche AG (CH) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007107470-A2 | PYRAZOLES AS 11-BETA-HSD-1 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-09-27 | — | — | WO | disclosed |