Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PGK1 | P00558 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718225 | 0.92 | PDE10A (0.45) | PDE10ASMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL3210986 | 0.87 | PDE10A (0.42) | PDE10ASMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL3215498 | 0.85 | LMNA (0.43) | PDE10ASMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL3218775 | 0.82 | MAPT (0.41) | SMN1; SMN2HTTALDH1A1NPSR1KDM4E | |
| SCHEMBL3217299 | 0.82 | TLR8 (0.54) | PDE10AKMT2AMEN1HSP90AA1HSP90AB1 | |
| SCHEMBL3208073 | 0.80 | PDE10A (0.39) | PDE10AHTTALDH1A1MAPTL3MBTL1 | |
| SCHEMBL3219124 | 0.77 | KDM4E (0.47) | LMNAHTTALDH1A1HPGDKDM4E | |
| SCHEMBL3203933 | 0.76 | AKT1 (0.40) | ALDH1A1MAPTPGK1L3MBTL1HSP90AA1 | |
| SCHEMBL3210074 | 0.76 | TLR8 (0.41) | SMN1; SMN2HTTALDH1A1KDM4EKMT2A | |
| SCHEMBL3218819 | 0.76 | NQO2 (0.42) | KMT2AMEN1HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917245-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | Abbott GmbH & Co. KG (DE) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007022946-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBOTT GMBH & CO. KG (DE) | 2007-03-01 | — | — | WO | disclosed |