Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butyric Acid SCHEMBL4155289 | 0.91 | RXFP1 (0.47) | RXFP1VCAM1SMN1; SMN2POLBKDM4E | |
| Butyric Acid SCHEMBL4162647 | 0.83 | RXFP1 (0.42) | RXFP1VCAM1SMN1; SMN2POLBKDM4E | |
| Butyric Acid SCHEMBL4155200 | 0.80 | RXFP1 (0.40) | RXFP1VCAM1SMN1; SMN2POLBKDM4E | |
| Propionic Acid SCHEMBL4162945 | 0.78 | KDM4E (0.47) | RXFP1KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL3247255 | 0.78 | RXFP1 (0.42) | RXFP1VCAM1SMN1; SMN2POLBKDM4E | |
| SCHEMBL8415895 | 0.78 | SMN1; SMN2 (0.62) | RXFP1VCAM1SMN1; SMN2POLBKDM4E | |
| Butyric Acid SCHEMBL4155243 | 0.78 | KDM4E (0.39) | RXFP1SMN1; SMN2POLBKDM4EALDH1A1 | |
| SCHEMBL4714478 | 0.77 | RXFP1 (0.43) | RXFP1VCAM1POLBKDM4EALDH1A1 | |
| SCHEMBL4717999 | 0.77 | RXFP1 (0.43) | RXFP1SMN1; SMN2POLBKDM4EALDH1A1 | |
| SCHEMBL4714760 | 0.77 | RXFP1 (0.42) | RXFP1KDM4EBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | disclosed |