Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4719129 | 0.96 | HRH3 (0.40) | HRH3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4723575 | 0.91 | HRH3 (0.40) | HRH3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4719309 | 0.89 | PDE4A (0.39) | HRH3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4721150 | 0.89 | PDE4A (0.42) | HRH3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4723846 | 0.88 | PDE4B (0.38) | HRH3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4719833 | 0.86 | PDE4A (0.35) | HRH3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4719466 | 0.86 | PDE4A (0.41) | HRH3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4722084 | 0.86 | PDE4A (0.35) | HRH3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4721104 | 0.85 | PLK1 (0.35) | HRH3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4721220 | 0.85 | PDE4A (0.35) | HRH3PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |