Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 17/20 | 0.50 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.43 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4088326 | 0.89 | CHEK2 (0.44) | CHEK2PKN1PKN2CHEK1 | |
| SCHEMBL15534807 | 0.79 | CHEK2 (0.46) | CHEK2PKN1PKN2 | |
| SCHEMBL1180188 | 0.71 | NPC1 (0.47) | — | |
| Hydrochloric Acid SCHEMBL4972256 | 0.69 | GRM2 (0.44) | CHEK2PKN2CHEK1 | |
| SCHEMBL24976057 | 0.69 | IP6K1 (0.48) | CHEK2IP6K1 | |
| SCHEMBL31428714 | 0.69 | IP6K1 (0.48) | CHEK2IP6K1 | |
| SCHEMBL1181806 | 0.68 | ACHE (0.41) | — | |
| SCHEMBL4507302 | 0.68 | CHEK2 (0.59) | CHEK2PKN1PKN2CHEK1 | |
| SCHEMBL31428846 | 0.67 | IP6K1 (0.46) | CHEK2PKN2IP6K1CHEK1 | |
| SCHEMBL24976114 | 0.67 | IP6K1 (0.46) | CHEK2PKN2IP6K1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940840-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007045758-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2007-04-26 | — | — | WO | disclosed |