Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR8 | P51685 | 10/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4721447 | 0.87 | CCR8 (0.74) | CCR8KCNH2HCRTR1HCRTR2ADRA1B | |
| SCHEMBL3919797 | 0.85 | CCR8 (1.00) | CCR8KCNH2 | |
| SCHEMBL3919790 | 0.85 | CCR8 (1.00) | CCR8KCNH2 | |
| SCHEMBL4718696 | 0.81 | CCR8 (0.53) | CCR8KCNH2ADRA1B | |
| SCHEMBL4716924 | 0.74 | CCR8 (0.53) | CCR8KCNH2ADRA1B | |
| SCHEMBL3930474 | 0.72 | CCR8 (1.00) | CCR8KCNH2 | |
| SCHEMBL3930467 | 0.72 | CCR8 (1.00) | CCR8KCNH2 | |
| SCHEMBL4721450 | 0.72 | CCR8 (0.53) | CCR8KCNH2ADRA1B | |
| SCHEMBL3923700 | 0.70 | CCR8 (0.69) | CCR8KCNH2 | |
| SCHEMBL3923708 | 0.70 | CCR8 (0.69) | CCR8KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567520-B1 | QUINOLINES AND NITROGENATED DERIVATIVES THEREOF AND THEIR USE AS ANTIBACTERIAL AGENTS | GLAXO GROUP LTD (GB) | 2008-10-15 | — | — | EP | claimed |