Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4714512 | 0.98 | CHRM5 (0.43) | CHRM5ADRA2CHRH3CYP1A2KCNH2 | |
| SCHEMBL3078766 | 0.82 | GAA (0.36) | HRH3CYP1A2SIGMAR1 | |
| SCHEMBL4715901 | 0.82 | RAD52 (0.36) | CHRM5ADRA2CHRH3SIGMAR1 | |
| SCHEMBL4716639 | 0.82 | GAA (0.36) | HRH3CYP1A2SIGMAR1 | |
| SCHEMBL9245345 | 0.74 | CYP1A2 (0.62) | CHRM5ADRA2CHRH3CYP1A2 | |
| SCHEMBL9927921 | 0.74 | CYP1A2 (0.62) | CHRM5ADRA2CHRH3CYP1A2 | |
| SCHEMBL6079950 | 0.74 | CYP1A2 (0.62) | CHRM5ADRA2CHRH3CYP1A2 | |
| SCHEMBL12568585 | 0.74 | CYP1A2 (0.62) | CHRM5ADRA2CHRH3CYP1A2 | |
| SCHEMBL4718925 | 0.74 | CYP1A2 (0.62) | CHRM5ADRA2CHRH3CYP1A2 | |
| SCHEMBL2760246 | 0.71 | CYP1A2 (0.59) | CHRM5ADRA2CCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490367-B1 | IMIDAZOPYRIDINE DERIVATIVES AS KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-07-23 | — | — | EP | claimed |
| US-7348339-B2 | 2-(4-amino-furazan-3-yl)-1-ethyl-N-[(2R)-2-morpholinylmethyl]-1H-imidazo[4,5-c]pyridine-7-carboxamide; Mitogen- and Stress-Activated Protein (MSK) and Rho (guanosine triphosphate) 1 or 2 kinase inhibitor; neurodegenerative diaeases; antiinflammatory, anticarcinogenic, antiviral and antibacterial agent | GLAXO GROUP LIMITED (GB) | 2008-03-25 | — | — | US | claimed |