Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 16/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3939247 | 0.81 | CYP3A4 (0.53) | GPR119CYP3A4MMP13KDM4EALDH1A1 | |
| SCHEMBL13941032 | 0.79 | CYP3A4 (0.56) | GPR119CYP3A4MMP13KDM4EALDH1A1 | |
| SCHEMBL5765295 | 0.79 | GPR119 (0.44) | GPR119KDM4E | |
| SCHEMBL3936734 | 0.79 | CYP3A4 (0.51) | GPR119CYP3A4MMP13KDM4EALDH1A1 | |
| SCHEMBL5763519 | 0.77 | GPR119 (0.44) | GPR119KDM4E | |
| SCHEMBL3942539 | 0.76 | CYP3A4 (0.46) | GPR119CYP3A4MMP13KDM4EALDH1A1 | |
| SCHEMBL3940021 | 0.76 | CYP3A4 (0.52) | GPR119CYP3A4MMP13MMP7 | |
| SCHEMBL3943472 | 0.75 | GAA (0.46) | GPR119KDM4E | |
| SCHEMBL13923649 | 0.75 | CYP3A4 (0.80) | GPR119CYP3A4MMP13MMP7 | |
| SCHEMBL3940017 | 0.74 | CYP3A4 (0.72) | GPR119CYP3A4MMP13MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644340-B1 | N-[({'4-SUBSTITUTED PIPERAZINE-1-YL}SULFONYLMETHYL)ALKYL]-N-HYDROXYFORMAMIDE COMPOUNDS AS METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-11-12 | — | — | EP | disclosed |