Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL3407658 | 0.79 | HSD17B10 (0.47) | HSD17B10KDM4ETDP1USP2ESR1 | |
| Bromide SCHEMBL9802105 | 0.79 | HSD17B10 (0.47) | HSD17B10KDM4ETDP1USP2ESR1 | |
| Bromide SCHEMBL9802090 | 0.79 | HSD17B10 (0.47) | HSD17B10KDM4ETDP1USP2ESR1 | |
| Bromide SCHEMBL9802079 | 0.79 | HSD17B10 (0.47) | HSD17B10KDM4ETDP1USP2ESR1 | |
| Bromide SCHEMBL9801849 | 0.78 | HSD17B10 (0.67) | HSD17B10KDM4ETDP1USP2ESR1 | |
| Bromide SCHEMBL3345174 | 0.78 | HSD17B10 (0.67) | HSD17B10KDM4ETDP1USP2ESR1 | |
| Bromide SCHEMBL9801855 | 0.78 | HSD17B10 (0.67) | HSD17B10KDM4ETDP1USP2ESR1 | |
| SCHEMBL9802876 | 0.76 | HSD17B10 (0.68) | HSD17B10KDM4ETDP1USP2ESR1 | |
| SCHEMBL9802883 | 0.76 | HSD17B10 (0.68) | HSD17B10KDM4ETDP1USP2ESR1 | |
| SCHEMBL9802867 | 0.76 | HSD17B10 (0.68) | HSD17B10KDM4ETDP1USP2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996202-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007104933-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-09-20 | — | — | WO | disclosed |