Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | PDE5A | O76074 | 3/20 | 0.38 |
| ▸ | PDE4A | P27815 | 3/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.36 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.36 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.36 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.36 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4720423 | 0.87 | GRK6 (0.39) | PDE5ACDK1CDK2KDM4E | |
| SCHEMBL4724671 | 0.81 | HTR1B (0.44) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4720440 | 0.80 | ABCG2 (0.42) | CYP1A2CYP2C9MAPK1KDM4ETP53 | |
| SCHEMBL4720942 | 0.74 | HTR1B (0.41) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4723292 | 0.73 | CYP2C9 (0.44) | CYP1A2CYP2C9CYP2C19LTA4HCSNK1D | |
| SCHEMBL4765647 | 0.69 | CYP2C9 (0.46) | CYP1A2CYP2C9CYP2C19LTA4HCSNK1D | |
| SCHEMBL30002666 | 0.69 | CYP1A2 (0.46) | CYP1A2CYP2C9CYP2C19LTA4HKDM4E | |
| SCHEMBL4723591 | 0.68 | ENPP1 (0.42) | PDE5AMAPK1GSK3BKDM4EHTR1B | |
| 1,2-Dibutoxybenzene SCHEMBL29428927 | 0.68 | CYP1A2 (0.72) | CYP1A2CYP2C9CYP2C19LTA4HKDM4E | |
| 1,2-Dibutoxybenzene SCHEMBL1226749 | 0.68 | CYP1A2 (0.72) | CYP1A2CYP2C9CYP2C19LTA4HKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080176857-A1 | 4-Piperazinnylthieno[2,3-d]Pyrimidine Compounds as Platelet Aggregation Inhibitors | PFIZER INC. | 2008-07-24 | — | — | US | disclosed |
| EP-1874780-A1 | 4-PIPERAZINYLTHIENO[2,3-D]PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | Pharmacia & Upjohn Company LLC (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006100591-A1 | 4-PIPERAZINNYLTHIENO [2,3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-09-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176857-A1 | 4-Piperazinnylthieno[2,3-d]Pyrimidine Compounds as Platelet Aggregation Inhibitors | TBXA2R, P2RY4, PF4 | CYP1A2 427/4885CYP2C9 303/4885CYP2C19 195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.