Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.37 |
| ▸ | TACR2 | P21452 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.35 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | WNT3 | P56703 | 1/20 | 0.32 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.32 |
| ▸ | KRAS | P01116 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.30 |
| ▸ | XIAP | P98170 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718767 | 1.00 | ADRB2 (0.37) | ADRB2TACR2TACR1RAMP1CALCRL | |
| SCHEMBL5248989 | 0.81 | RAMP1 (0.42) | ADRB2RAMP1CALCRLENPP2LRRK2 | |
| SCHEMBL4849662 | 0.81 | RAMP1 (0.41) | ADRB2RAMP1CALCRLNOTUMLRRK2 | |
| SCHEMBL4720816 | 0.79 | RAMP1 (0.35) | ADRB2TACR1RAMP1CALCRLRORC | |
| SCHEMBL4804839 | 0.77 | TEAD1 (0.39) | ADRB2RAMP1CALCRLEPHX2 | |
| SCHEMBL5326014 | 0.74 | ACACB (0.35) | RAMP1CALCRLSLC9A1 | |
| SCHEMBL4798589 | 0.73 | TEAD1 (0.36) | ADRB2RAMP1CALCRLEPHX2 | |
| SCHEMBL3593151 | 0.70 | CNR2 (0.30) | — | |
| SCHEMBL4763044 | 0.70 | NOTUM (0.34) | KRASNOTUM | |
| SCHEMBL8190796 | 0.69 | SPHK1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558600-B1 | SELECTED CGRP ANTAGONISTS, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENT | BOEHRINGER INGELHEIM PHARMA (DE) | 2008-05-07 | — | — | EP | claimed |