Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 4/20 | 0.33 |
| ▸ | UGCG | Q16739 | 1/20 | 0.32 |
| ▸ | ULK1 | O75385 | 2/20 | 0.32 |
| ▸ | ULK2 | Q8IYT8 | 2/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | SMURF1 | Q9HCE7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4719123 | 0.97 | AR (0.37) | PDE4APDE4BPDE4CPDE4DGRM7 | |
| SCHEMBL4720922 | 0.89 | F10 (0.39) | PDE4APDE4BPDE4CPDE4DGRM7 | |
| SCHEMBL4722944 | 0.88 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DGRM7 | |
| SCHEMBL4724950 | 0.87 | UTS2R (0.36) | PDE4APDE4BPDE4CPDE4DGRM7 | |
| SCHEMBL4724044 | 0.87 | CNR2 (0.39) | PDE4APDE4BPDE4CPDE4DGRM7 | |
| SCHEMBL4720454 | 0.87 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DGRM7 | |
| SCHEMBL4724087 | 0.86 | UTS2R (0.35) | PDE4APDE4BPDE4CPDE4DGRM7 | |
| SCHEMBL4723085 | 0.86 | CNR2 (0.37) | PDE4APDE4BPDE4CPDE4DGRM7 | |
| SCHEMBL4721150 | 0.86 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DGRM7 | |
| SCHEMBL4722165 | 0.86 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |