Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | XDH | P47989 | 1/20 | 0.30 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4719190 | 0.94 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DGRM7 | |
| SCHEMBL4722014 | 0.89 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DGRM7 | |
| SCHEMBL4720223 | 0.88 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DGRM7 | |
| SCHEMBL14101906 | 0.88 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DGRM7 | |
| SCHEMBL4722238 | 0.87 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DGRM7 | |
| SCHEMBL14101702 | 0.87 | F10 (0.40) | PDE4APDE4BPDE4CPDE4DHRH3 | |
| SCHEMBL4720663 | 0.86 | PDE4A (0.36) | PDE4APDE4BPDE4CPDE4DGRM7 | |
| SCHEMBL4721150 | 0.86 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DGRM7 | |
| SCHEMBL4719764 | 0.84 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DGRM7 | |
| SCHEMBL4723635 | 0.83 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DGRM7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |