Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 16/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 16/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5332290 | 0.92 | SLC6A2 (0.48) | HTR2CSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5309381 | 0.84 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3 | |
| Trifluoroacetic Acid SCHEMBL1081692 | 0.81 | SLC6A2 (0.37) | HTR2CSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13114874 | 0.76 | CACNA2D1 (0.50) | SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL1231609 | 0.75 | HTR2C (0.53) | HTR2CSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5789580 | 0.71 | PTPN1 (0.41) | — | |
| SCHEMBL27599455 | 0.70 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL28821897 | 0.70 | ACP3 (0.53) | — | |
| SCHEMBL3130946 | 0.70 | ACP3 (0.53) | — | |
| SCHEMBL5995236 | 0.69 | SLC6A2 (0.59) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001848-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR THE TREATMENT OF DEMENTIA | MERCK SHARP & DOHME LTD. (GB) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007110667-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR THE TREATMENT OF DEMENTIA | MERCK SHARP & DOHME LIMITED (GB) | 2007-10-04 | — | — | WO | disclosed |
| EP-1805141-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LTD. (GB) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006043064-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2006-04-27 | — | — | WO | disclosed |