Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 12/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.43 |
| ▸ | CPN1 | P15169 | 1/20 | 0.41 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5332290 | 0.92 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3CHRM4CYP3A4 | |
| SCHEMBL4720830 | 0.84 | HTR2C (0.47) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27124181 | 0.81 | CPN1 (0.43) | SLC6A2SLC6A4SLC6A3CPN1CPB2 | |
| SCHEMBL27132169 | 0.80 | CPN1 (0.41) | SLC6A2SLC6A4SLC6A3CPN1CPB2 | |
| SCHEMBL27410776 | 0.78 | CPN1 (0.49) | SLC6A2SLC6A4SLC6A3CPN1CPB2 | |
| SCHEMBL27123836 | 0.75 | CPN1 (0.39) | SLC6A2SLC6A4SLC6A3CPN1CPB2 | |
| SCHEMBL16475935 | 0.70 | CPN1 (0.47) | SLC6A2SLC6A4SLC6A3CPN1CPB2 | |
| SCHEMBL5789580 | 0.70 | PTPN1 (0.41) | CNR1 | |
| SCHEMBL18547184 | 0.69 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL31066542 | 0.69 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805141-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LTD. (GB) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006043064-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2006-04-27 | — | — | WO | disclosed |