Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31530569 | 0.72 | ALDH1A1 (0.66) | ALDH1A1MAPTMDM2TSHRNPSR1 | |
| SCHEMBL16026437 | 0.69 | ALDH1A1 (0.83) | ALDH1A1MAPTTSHRTP53NPSR1 | |
| SCHEMBL643306 | 0.69 | ALDH1A1 (0.66) | ALDH1A1MAPTTSHRTP53NPSR1 | |
| SCHEMBL6754203 | 0.68 | DRD1 (0.49) | ALDH1A1MAPTTSHRTP53HTT | |
| SCHEMBL31530558 | 0.67 | NAMPT (0.61) | ALDH1A1MAPTMDM2TSHRTP53 | |
| SCHEMBL2580863 | 0.67 | ALDH1A1 (0.55) | ALDH1A1MAPTMDM2TSHRTP53 | |
| Ethylene SCHEMBL8377759 | 0.67 | ALDH1A1 (0.62) | ALDH1A1MAPTTSHRTP53NPSR1 | |
| SCHEMBL2932922 | 0.66 | ALDH1A1 (0.66) | ALDH1A1MAPTTSHRTP53NPSR1 | |
| SCHEMBL61103 | 0.65 | ALDH1A1 (0.87) | ALDH1A1MAPTTSHRTP53NPSR1 | |
| SCHEMBL4748498 | 0.65 | ALDH1A1 (0.87) | ALDH1A1MAPTTSHRTP53NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725553-B1 | TETRAHYDROPYRIDOINDOLE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-05-07 | — | — | EP | claimed |