Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.44 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL391546 | 0.88 | GPR119 (0.59) | GPR119IRAK4 | |
| SCHEMBL4719041 | 0.87 | GPR119 (0.51) | GPR119HCRTR1HCRTR2CDK2FLT3 | |
| SCHEMBL4721951 | 0.87 | GPR119 (0.58) | GPR119IRAK4CDK2 | |
| SCHEMBL4719015 | 0.86 | GPR119 (0.46) | GPR119IKBKETBK1CDK2FLT3 | |
| SCHEMBL4723727 | 0.85 | GPR119 (0.47) | GPR119IKBKETBK1 | |
| SCHEMBL4721992 | 0.83 | GPR119 (0.43) | GPR119CDK2FLT3CDK6CCNE1 | |
| SCHEMBL4723387 | 0.81 | GPR119 (0.49) | GPR119CDK2FLT3CDK6 | |
| SCHEMBL4722086 | 0.81 | GPR119 (0.43) | GPR119IKBKETBK1JAK2 | |
| SCHEMBL4723713 | 0.81 | GPR119 (0.53) | GPR119CDK2FLT3CDK6 | |
| SCHEMBL4723272 | 0.80 | GPR119 (0.46) | GPR119CDK2FLT3CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |