Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 15/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4722575 | 0.89 | PARP1 (0.61) | PARP1KDM4EPDE4APDE4BPDE4C | |
| SCHEMBL5528097 | 0.85 | PARP1 (0.67) | PARP1KDM4E | |
| SCHEMBL9958688 | 0.82 | PARP1 (0.62) | PARP1KDM4E | |
| SCHEMBL5534217 | 0.82 | PARP1 (0.64) | PARP1KDM4E | |
| SCHEMBL5525828 | 0.81 | PARP1 (0.64) | PARP1KDM4E | |
| SCHEMBL5534192 | 0.80 | PARP1 (0.62) | PARP1KDM4E | |
| SCHEMBL4723008 | 0.79 | PARP1 (0.56) | PARP1KDM4E | |
| SCHEMBL5534001 | 0.79 | PARP1 (0.58) | PARP1KDM4E | |
| SCHEMBL5523598 | 0.79 | PARP1 (0.60) | PARP1KDM4E | |
| SCHEMBL5532493 | 0.79 | PARP1 (0.60) | PARP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989204-A1 | PYRAZOLOQUINOLONES ARE POTENT PARP INHIBITORS | Abbott Laboratories (US) | 2008-11-12 | — | — | EP | disclosed |
| WO-2007095628-A1 | PYRAZOLOQUINOLONES ARE POTENT PARP INHIBITORS | ABBOTT LABORATORIES (US) | 2007-08-23 | — | — | WO | disclosed |