Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 3/20 | 0.43 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.35 |
| ▸ | PRKX | P51817 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.35 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.35 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4774113 | 0.77 | CENPE (0.54) | CENPEKIFC1TAS1R3TAS1R1ROCK2 | |
| SCHEMBL3229399 | 0.76 | CENPE (0.52) | CENPEKIFC1TAS1R3TAS1R1ROCK2 | |
| SCHEMBL2106289 | 0.76 | CENPE (0.53) | CENPEKIFC1TAS1R3TAS1R1ROCK2 | |
| SCHEMBL3233445 | 0.75 | CENPE (0.52) | CENPEKIFC1TAS1R3TAS1R1ROCK2 | |
| SCHEMBL13711223 | 0.75 | CENPE (0.54) | CENPEKIFC1TAS1R3TAS1R1ROCK2 | |
| SCHEMBL2617412 | 0.75 | CENPE (0.54) | CENPEKIFC1TAS1R3TAS1R1ROCK2 | |
| SCHEMBL2104926 | 0.74 | CENPE (0.56) | CENPEKIFC1TAS1R3TAS1R1S1PR1 | |
| SCHEMBL13626726 | 0.74 | CENPE (0.53) | CENPEKIFC1TAS1R3TAS1R1ROCK2 | |
| SCHEMBL2101923 | 0.73 | CENPE (0.51) | CENPETAS1R3TAS1R1ROCK2PRKACA | |
| SCHEMBL3469159 | 0.73 | CENPE (0.51) | CENPETAS1R3TAS1R1ROCK2PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951719-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007056469-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |