Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.33 |
| ▸ | PPARD | Q03181 | 3/20 | 0.33 |
| ▸ | PPARA | Q07869 | 3/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5423224 | 0.90 | PDE3B (0.36) | NPC1MAPK14ATP4AATP4B | |
| SCHEMBL23553880 | 0.90 | NR1H2 (0.35) | THRATHRBNR1H2PPARDPPARA | |
| SCHEMBL9101422 | 0.89 | MAPK14 (0.37) | PPARAMEN1RAB9AKMT2APPARG | |
| SCHEMBL5430460 | 0.88 | NPC1 (0.39) | THRATHRBPPARDS1PR1S1PR4 | |
| SCHEMBL5428996 | 0.88 | MEN1 (0.41) | THRATHRBS1PR1S1PR4S1PR5 | |
| SCHEMBL4656403 | 0.82 | MAPK14 (0.46) | MEN1RAB9AKMT2ANPC1ALDH1A1 | |
| SCHEMBL4655528 | 0.81 | THRA (0.41) | THRATHRBNR1H2PPARDPPARA | |
| SCHEMBL9098567 | 0.81 | S1PR4 (0.40) | THRATHRBS1PR1S1PR4S1PR5 | |
| SCHEMBL4656609 | 0.81 | MAPK14 (0.47) | THRATHRBS1PR1S1PR4S1PR5 | |
| SCHEMBL5425206 | 0.80 | MAPK14 (0.46) | THRATHRBS1PR1S1PR4S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996565-A2 | SUBSTITUTED AMINOTHIAZOLE DERIVATIVES WITH ANTI-HCV ACTIVITY | Achillion Pharmaceuticals, Inc. (US) | 2008-12-03 | — | — | EP | claimed |
| WO-2007103550-A2 | SUBSTITUTED AMINOTHIAZOLE DERIVATIVES WITH ANTI-HCV ACTIVITY | ACHILLION PHARMACEUTICALS, INC. (US) | 2007-09-13 | — | — | WO | claimed |