Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 18/20 | 0.62 |
| ▸ | CCND1 | P24385 | 17/20 | 0.62 |
| ▸ | CCND2 | P30279 | 8/20 | 0.62 |
| ▸ | CCND3 | P30281 | 8/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.62 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.62 |
| ▸ | FGFR4 | P22455 | 6/20 | 0.62 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.62 |
| ▸ | CDK2 | P24941 | 9/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.60 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.60 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.59 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30672719 | 0.85 | CDK4 (0.52) | CDK4CCND1CCND2CCND3FGFR1 | |
| SCHEMBL31194193 | 0.83 | CDK4 (0.58) | CDK4CCND1CCND2CCND3FGFR1 | |
| SCHEMBL23201581 | 0.82 | CDK4 (0.63) | CDK4CCND1CCND2CCND3FGFR1 | |
| SCHEMBL22345790 | 0.80 | CDK4 (0.56) | CDK4CCND1CCND2CCND3FGFR1 | |
| SCHEMBL16486429 | 0.77 | CDK4 (0.66) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL30950888 | 0.77 | CDK4 (0.48) | CDK4CCND1CCND2CCND3FGFR1 | |
| SCHEMBL4830665 | 0.77 | CDK4 (1.00) | CDK4CCND1CCND2CCND3FGFR1 | |
| SCHEMBL4833287 | 0.77 | CDK4 (0.78) | CDK4CCND1CCND2CCND3FGFR1 | |
| SCHEMBL4830895 | 0.77 | CDK4 (0.70) | CDK4CCND1CCND2CCND3FGFR1 | |
| SCHEMBL29507611 | 0.77 | CDK4 (1.00) | CDK4CCND1CCND2CCND3FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648889-A1 | ISETHIONATE SALT OF A SELECTIVE CDK4 INHIBITOR | Warner-Lambert Company LLC (US) | 2006-04-26 | — | — | EP | claimed |
| WO-2005005426-A1 | ISETHIONATE SALT OF A SELECTIVE CDK4 INHIBITOR | WARNER-LAMBERT COMPANY LLC (US) | 2005-01-20 | — | — | WO | claimed |
| EP-1648889-B1 | ISETHIONATE SALT OF A SELECTIVE CDK4 INHIBITOR | WARNER LAMBERT CO (US) | 2008-10-29 | — | — | EP | disclosed |
| EP-1648889-A1 | ISETHIONATE SALT OF A SELECTIVE CDK4 INHIBITOR | Warner-Lambert Company LLC (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005005426-A1 | ISETHIONATE SALT OF A SELECTIVE CDK4 INHIBITOR | WARNER-LAMBERT COMPANY LLC (US) | 2005-01-20 | — | — | WO | disclosed |