Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | UGCG | Q16739 | 2/20 | 0.38 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.38 |
| ▸ | ITGAL | P20701 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | SMPD3 | Q9NY59 | 3/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4723378 | 1.00 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DUGCG | |
| SCHEMBL4721025 | 0.94 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DUGCG | |
| SCHEMBL4721029 | 0.94 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DUGCG | |
| SCHEMBL4724045 | 0.94 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DUGCG | |
| SCHEMBL4724049 | 0.94 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DUGCG | |
| SCHEMBL4721562 | 0.92 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DUGCG | |
| SCHEMBL4721557 | 0.92 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DUGCG | |
| SCHEMBL4722090 | 0.92 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DUGCG | |
| SCHEMBL4722087 | 0.92 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DUGCG | |
| SCHEMBL4722940 | 0.91 | P2RX7 (0.40) | PDE4APDE4BPDE4CPDE4DP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |