Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 10/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4723392 | 1.00 | NOTUM (0.48) | NOTUMARCDK1CDK2HSD11B1 | |
| SCHEMBL2935853 | 0.84 | NOTUM (0.49) | NOTUMARCDK1CDK2HSD11B1 | |
| SCHEMBL1409422 | 0.81 | NOTUM (0.67) | NOTUMARHSD11B1 | |
| SCHEMBL4721681 | 0.80 | NOTUM (0.44) | NOTUMARCDK1CDK2HSD11B1 | |
| SCHEMBL2050734 | 0.80 | NOTUM (0.49) | NOTUMARCDK1CDK2HSD11B1 | |
| SCHEMBL2050735 | 0.80 | NOTUM (0.49) | NOTUMARCDK1CDK2HSD11B1 | |
| SCHEMBL1409621 | 0.80 | NOTUM (0.68) | NOTUMAR | |
| SCHEMBL2971480 | 0.80 | NOTUM (0.49) | NOTUMARCDK1CDK2HSD11B1 | |
| SCHEMBL4722110 | 0.80 | AR (0.62) | NOTUMARCDK1CDK2HSD11B1 | |
| SCHEMBL4722109 | 0.80 | AR (0.62) | NOTUMARCDK1CDK2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |