Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28428414 | 0.78 | CHRM2 (0.55) | CHRNB2CHRNA4ALDH1A1MEN1CASP1 | |
| SCHEMBL2913826 | 0.75 | CHRNB2 (0.45) | CHRNB2CHRNA4ALDH1A1CHRM2CHRM4 | |
| SCHEMBL8275384 | 0.75 | CHRNB2 (0.45) | CHRNB2CHRNA4ALDH1A1CHRM2CHRM4 | |
| SCHEMBL14811086 | 0.75 | CHRNB2 (0.45) | CHRNB2CHRNA4ALDH1A1MEN1CASP1 | |
| SCHEMBL18660627 | 0.75 | CHRNB2 (0.45) | CHRNB2CHRNA4ALDH1A1MEN1CASP1 | |
| SCHEMBL14377332 | 0.75 | CHRNB2 (0.45) | CHRNB2CHRNA4ALDH1A1MEN1CASP1 | |
| SCHEMBL5108619 | 0.75 | CHRNB2 (0.42) | CHRNB2CHRNA4ALDH1A1MEN1CASP1 | |
| SCHEMBL721835 | 0.73 | CHRNB2 (0.44) | CHRNB2CHRNA4ALDH1A1MEN1CASP1 | |
| SCHEMBL30765277 | 0.73 | CHRNB2 (0.44) | CHRNB2CHRNA4ALDH1A1MEN1CASP1 | |
| SCHEMBL7848655 | 0.73 | CHRM2 (0.51) | CHRNB2CHRNA4ALDH1A1MEN1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115040532-A | Treatment of cancer using TLR9 agonists and checkpoint inhibitors | 伊黛拉制药有限公司 | 2022-09-13 | — | — | CN | disclosed |
| CN-106999574-B | Treatment of cancer using TLR9 agonists and checkpoint inhibitors | 伊黛拉制药有限公司 | 2022-05-24 | — | — | CN | disclosed |
| EP-1934228-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007027855-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2007-03-08 | — | — | WO | disclosed |
| US-20070049603-A1 | Raf inhibitor compounds and methods of use thereof | ARRAY BIOPHARMA INC. | 2007-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049603-A1 | Raf inhibitor compounds and methods of use thereof | BRAF, RAF1, ARAF | CHRNB2 4699/4885CHRNA4 4867/4885ALDH1A1 1842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.