Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4723739 | 1.00 | PDE3B (0.34) | PDE3BPDE3AP2RX7SOS1HSD11B1 | |
| SCHEMBL4723031 | 0.91 | P2RX7 (0.37) | PDE3BPDE3AP2RX7SOS1HSD11B1 | |
| SCHEMBL4723038 | 0.91 | P2RX7 (0.37) | PDE3BPDE3AP2RX7SOS1HSD11B1 | |
| SCHEMBL4720122 | 0.90 | P2RX7 (0.34) | PDE3BPDE3AP2RX7SOS1 | |
| SCHEMBL4719218 | 0.90 | P2RX7 (0.34) | PDE3BPDE3AP2RX7SOS1 | |
| SCHEMBL4719220 | 0.90 | P2RX7 (0.34) | PDE3BPDE3AP2RX7SOS1 | |
| SCHEMBL4723851 | 0.88 | PDE3B (0.34) | PDE3BPDE3AP2RX7SOS1HSD11B1 | |
| SCHEMBL4723849 | 0.88 | PDE3B (0.34) | PDE3BPDE3AP2RX7SOS1HSD11B1 | |
| SCHEMBL4720289 | 0.88 | P2RX7 (0.36) | PDE3BPDE3AP2RX7SOS1HSD11B1 | |
| SCHEMBL4720292 | 0.88 | P2RX7 (0.36) | PDE3BPDE3AP2RX7SOS1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |