Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGA | O60502 | 8/20 | 0.56 |
| ▸ | ACHE | P22303 | 4/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | SORD | Q00796 | 1/20 | 0.40 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4948656 | 0.79 | HRH4 (0.56) | OGAACHE | |
| SCHEMBL29958994 | 0.79 | HRH4 (0.56) | OGAACHE | |
| SCHEMBL4755801 | 0.79 | OGA (0.51) | OGA | |
| SCHEMBL4947574 | 0.77 | KDM1A (0.48) | OGAACHEKDM1A | |
| SCHEMBL10187275 | 0.77 | KDM1A (0.48) | OGAACHEKDM1A | |
| SCHEMBL4498304 | 0.77 | OGA (0.48) | OGAACHEKDM1ASORD | |
| SCHEMBL9900073 | 0.75 | KDM1A (0.47) | OGAACHEKDM1A | |
| SCHEMBL4764853 | 0.74 | GRIN2D (0.47) | OGA | |
| SCHEMBL24827231 | 0.73 | ACHE (0.52) | OGAACHEKDM1A | |
| SCHEMBL22119525 | 0.73 | OGA (0.44) | OGAKDM1APTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917262-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007020194-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS P2X3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-22 | — | — | WO | disclosed |